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KMID : 1007520130220020501
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Food Science and Biotechnology
2013 Volume.22 No. 2 p.501 ~ p.506
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Chinese Quince (Chaenomeles sinensis) Extract Inhibits Cell Migration and Cytokine Release in HMC-1 Cells
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Kim Do-Hyung
Lee Ji-Sook
Yun Chi-Young
Kim Dong-Hee
Kim In-Sik
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Abstract
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Chinese quince (Chaenomeles sinensis; CS) is known as a traditional oriental medicine for treating anaphylaxis and viral infection. Mast cells play an important role in a variety of inflammatory diseases. The inhibitory effects of CS extract on the inflammatory response of human mast cells were examined. CS extract inhibited HMC-1 cell migration in response to stem cell factor (SCF). Its mechanism is involved in the inhibition of a surface expression of c-kit binding to SCF. Tumor necrosis factor (TNF)-α expression is induced by phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI). CS extract inhibited the TNF-α expression by blocking the activation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), and c-Jun-N-terminal kinase (JNK) in HMC-1 cells. CS extract suppressed the expression of interlukin (IL)-6, IL-8, and MCP-1 in human monocytic THP-1 cells, as well as the secretion of IL-6 in human keratinocytic HaCaT cells.
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KEYWORD
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Chinese quince (Chaenomeles sinensis), mast cell, anti-inflammatory effect, mitogen-activated protein kinase
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